Over two decades after finishing her documentary Gendernauts in 1999, Monika Treut returns to California to meet the protagonists of her groundbreaking queer film. Sandy Stone, Susan Stryker, Stafford and Max Valerio were once the young pioneers of the trans movement and almost all of them lived in San Francisco, back then the mekka for outsiders. Today they are between 50 and 80 years old, and hardly anyone can still afford to live in the city any more. But the energy of the gendernauts and their supporters Annie Sprinkle and Beth Stephens is unbroken. Genderation throws a utopian look back and shows the creative resistance of the gendernauts against the threatening living conditions in the US of A.